Chlorphentermine-induced abnormal cytoplasmic inclusions in peripheral blood cells of rats and guinea pigs
Identifieur interne : 003A24 ( Main/Exploration ); précédent : 003A23; suivant : 003A25Chlorphentermine-induced abnormal cytoplasmic inclusions in peripheral blood cells of rats and guinea pigs
Auteurs : Renate Lüllmann-Rauch [Allemagne]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1975.
English descriptors
- Teeft :
- Abnormal, Abnormal cytoplasmic inclusions, Abnormal inclusions, Amphiphilic, Amphiphilic compounds, Animal experiments, Basisof, Blood cell changes, Blood cells, Cellular alterations, Chlorphentermine, Control rats, Cytoplasmic, Cytosomes, Generalized phospholipidosis, Guinea, Guinea pigs, Human blood cells, Inclusion, Lamellar, Lamellar inclusions, Lamellated, Lamellated inclusions, Liillmann, Lymph nodes, Lymphocyte, Neutrophil, Other amphiphilic compounds, Peripheral blood, Peripheral blood cells, Peripheral blood lymphocytes, Peripheralblood, Pharmacol, Phospholipidosis, Plasma cell, Present observations, Shikata, Single dose, Treatedwith chlorphentermine, Tricyclic, Tricyclic antidepressants, Ultrastructural, Virchows arch, Wassermann, West germany.
Abstract
Abstract: Oral administration of chlorphentermine to rats and guinea pigs caused the formation of abnormal lamellated cytoplasmic inclusions in peripheral blood cells (lymphocytes, neutrophils, monocytes, plasma cells). Short-term experiments in rats revealed the lymphocytes to be most susceptible, containing abnormal inclusions after a single dose of chlorphentermine. The present ultrastructural findings correspond to those previously obtained in various other tissues of animals treated with chlorphentermine or with a variety of other drugs of amphiphilic character, and they are interpreted according to the previously proposed concept of drug-induced phospholipidosis. On the basis of the present results, lymphocytes of peripheral blood are proposed to be useful material for the examination of a particular side effect common to various amphiphilic compounds, i.e., drug-induced generalized phospholipidosis.
Url:
DOI: 10.1016/0041-008X(75)90192-1
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001902
- to stream Istex, to step Curation: 001902
- to stream Istex, to step Checkpoint: 002771
- to stream Main, to step Merge: 003B04
- to stream Main, to step Curation: 003A24
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Chlorphentermine-induced abnormal cytoplasmic inclusions in peripheral blood cells of rats and guinea pigs</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:267AD390F8E9447E51B45A3752D54B1370E72C54</idno><date when="1975" year="1975">1975</date><idno type="doi">10.1016/0041-008X(75)90192-1</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-CKFX1DP6-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001902</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001902</idno><idno type="wicri:Area/Istex/Curation">001902</idno><idno type="wicri:Area/Istex/Checkpoint">002771</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002771</idno><idno type="wicri:doubleKey">0041-008X:1975:Lullmann Rauch R:chlorphentermine:induced:abnormal</idno><idno type="wicri:Area/Main/Merge">003B04</idno><idno type="wicri:Area/Main/Curation">003A24</idno><idno type="wicri:Area/Main/Exploration">003A24</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Chlorphentermine-induced abnormal cytoplasmic inclusions in peripheral blood cells of rats and guinea pigs</title><author><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anatomy, University of Kiel, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1975">1975</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="32">32</biblScope><biblScope unit="page" to="39">39</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormal</term><term>Abnormal cytoplasmic inclusions</term><term>Abnormal inclusions</term><term>Amphiphilic</term><term>Amphiphilic compounds</term><term>Animal experiments</term><term>Basisof</term><term>Blood cell changes</term><term>Blood cells</term><term>Cellular alterations</term><term>Chlorphentermine</term><term>Control rats</term><term>Cytoplasmic</term><term>Cytosomes</term><term>Generalized phospholipidosis</term><term>Guinea</term><term>Guinea pigs</term><term>Human blood cells</term><term>Inclusion</term><term>Lamellar</term><term>Lamellar inclusions</term><term>Lamellated</term><term>Lamellated inclusions</term><term>Liillmann</term><term>Lymph nodes</term><term>Lymphocyte</term><term>Neutrophil</term><term>Other amphiphilic compounds</term><term>Peripheral blood</term><term>Peripheral blood cells</term><term>Peripheral blood lymphocytes</term><term>Peripheralblood</term><term>Pharmacol</term><term>Phospholipidosis</term><term>Plasma cell</term><term>Present observations</term><term>Shikata</term><term>Single dose</term><term>Treatedwith chlorphentermine</term><term>Tricyclic</term><term>Tricyclic antidepressants</term><term>Ultrastructural</term><term>Virchows arch</term><term>Wassermann</term><term>West germany</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Oral administration of chlorphentermine to rats and guinea pigs caused the formation of abnormal lamellated cytoplasmic inclusions in peripheral blood cells (lymphocytes, neutrophils, monocytes, plasma cells). Short-term experiments in rats revealed the lymphocytes to be most susceptible, containing abnormal inclusions after a single dose of chlorphentermine. The present ultrastructural findings correspond to those previously obtained in various other tissues of animals treated with chlorphentermine or with a variety of other drugs of amphiphilic character, and they are interpreted according to the previously proposed concept of drug-induced phospholipidosis. On the basis of the present results, lymphocytes of peripheral blood are proposed to be useful material for the examination of a particular side effect common to various amphiphilic compounds, i.e., drug-induced generalized phospholipidosis.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Lullmann Rauch, Renate" sort="Lullmann Rauch, Renate" uniqKey="Lullmann Rauch R" first="Renate" last="Lüllmann-Rauch">Renate Lüllmann-Rauch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003A24 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003A24 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:267AD390F8E9447E51B45A3752D54B1370E72C54
|texte= Chlorphentermine-induced abnormal cytoplasmic inclusions in peripheral blood cells of rats and guinea pigs
}}
| This area was generated with Dilib version V0.6.33. |  |